Dados do Trabalho

Título

PERFIL E PROGNOSTICO DE RECIDIVAS EM COORTE DE PACIENTES COM CANCER DE MAMA E LINFONODO SENTINELA NEGATIVO, TRATADAS NO HOSPITAL DO SERVIDOR ESTADUAL DE SAO PAULO.

Título em Inglês

RECURRENCE PROFILE AND PROGNOSIS IN A NEGATIVE SENTINEL LYMPH NODE BREAST CANCER PATIENTS COHORT TREATED AT HOSPITAL DO SERVIDOR ESTADUAL DE SÃO PAULO

Introdução

Breast cancer is the main cause of death by cancer among brazilian women and its incidence increases annually. Due to screening e new technologies, diagnosis without axillary metastasis is increasing.

Objetivos

This study aims to evaluate locoregional recurrences, distant metastasis, prognostic factors associated to those outcomes and its impact on deaths among breast cancer patients treated in a public hospital of São Paulo.

Métodos

It is a retrospective cohort study that included 342 T1-3N0 breast cancer patients with negative sentinel lymph node biopsy submitted to primary surgery between March 2014 and March 2019 at Hospital do Servidor Público Estadual (HSPE). Primary outcomes were locoregional recurrence rate, distant metastasis rate, mortality, disease free survival and overall survival. Secondary outcomes were the association between primary outcomes and prognostic factors stablished in literature.

Resultados

During 1,5 to 6,4 years of follow up (median time 3,3 years), there was 3,8% locoregional recurrence cases, 4,1% distant metastasis and 3,8% deaths. Locoregional recurrence free survival in 3 years was 94,4% and metastasis free survival was 95,6%. Overall survival in 3 years was 97,2%. Was observed association between locoregional recurrence histological subtype and hormonal therapy; distant metastasis, histological subtype and tumor grade; deaths and tumor grade. The results evidence that locoregional recurrences increases distant metastasis, but do not reduce overall survival. On the other hand, distant metastasis decreases overall survival.

Conclusões

This study shows that breast cancer patients without axillary metastasis treated at HSPE presents consistent locoregional recurrence, metastasis and mortality patterns with the literature. Further studies with more participants and longer follow-up are necessary to evaluate relative risk of each prognostic factor included in the present research.

Palavras Chave

Early Breast Cancer, Recurrence, Sentinel Lymph node, Prognostic Factors

Área

TUMOR CELL, MOLECULAR BIOLOGY, PREDICTIVE AND PROGNOSTIC FACTORS - Prognosis Factors