Dados do Trabalho

Título

CARCINOMA LOBULAR: O RISCO DE DOENÇA NA MAMA CONTRALATERAL NAO E DURADOURO.

Título em Inglês

Lobular Breast carcinoma: The risk for contralateral breast is not permanent

Introdução

The invasive lobular carcinoma of the breast occurs in approximately 10% of breast cancers. The increased risk for multicentric and bilateral breast tumor in is well documented in the literature, but few data are available regarding the interval for occurrence of contralateral tumor.

Objetivos

This study aims to analyze the characteristics of the bilaterality of the lobular tumor and time to the occurrence of the bilateral tumor in comparison with non-lobular tumors.

Métodos

Retrospective, analytical study from the American Surveillance, Epidemiology and End Results Program (SEER) database. Patients with unilateral and bilateral breast cancer (synchronous and metachronous) were filtered from this database in women aged 20 to 75 years during the period from 2000 to 2017. Patients with cancers diagnosed in other organs were excluded. Definitions: Lobular carcinoma at the first diagnosis (LC): patients with lobular breast cancer at the diagnosis of the first neoplasm. Non-lobular carcinoma (NLC): patients with non-lobular carcinoma (ductal or special type) at diagnosis of the first neoplasm.

Resultados

We identified 560,608 patients with breast cancer, 19,792 of which were patients with bilateral tumors (3.5%) and 45,156 (8.0%) lobular tumors at the first diagnosis. Patients with LC had significantly more tumors in both breasts throughout the research period (6.3% vs. 3.3%; OR: 1.97; IC95% 1.89 - 2.06, p<0.001).
The time for occurrence of contralateral tumor varied widely between patients with lobular and non-lobular tumor. The LC patients presented the diagnosis of contralateral breast tumor much earlier, with 50% of the contralateral tumors diagnosed within 1 month, and 75% in the first 3 months, while the NLC patients presented 50% of the contralateral tumors in the first 3 months and 75% after 54 months of follow-up. Cox's multivariate analysis shows a higher risk of contralateral breast involvement in LC patients when corrected by age and estrogen receptor expression (RR 2.0; CI 95% 1.93 - 2.09; p<0.001). This increased risk is not sustained when patients with a tumor interval greater than 12 months (RR 1.04; IC95% 0.96 - 1.14; p=0.3).

Conclusões

Invasive lobular carcinoma is associated with a higher incidence of contralateral disease, but the higher risk occurs in the first year of follow-up. After the 1-year period, the incidence of contralateral breast cancer is similar in lobular and non-lobular cancers.

Palavras Chave

breast neoplasms, lobular cancer, bilateral cancer

Área

EPIDEMIOLOGY, RISK, AND PREVENTION - Epidemiology