XXIII Congresso Brasileiro de Mastologia

Dados do Trabalho


Título

RELAÇAO ENTRE A CARACTERIZAÇAO IMUNO-HISTOQUIMICA E A FORMA DE DIANGNOSTICO DO CANCER DE MAMA

Título em Inglês

RELATIONSHIP BETWEEN IMMUNO-HISTOCHEMICAL CHARACTERIZATION AND THE FORM OF DIAGNOSIS OF BREAST CANCER

Introdução

Breast cancer is the most incident neoplasia in Brazilian women. According to immuno-genetic characteristics, it is possible to verify that malignant breast neoplasms with greater biological activity would be those classified as luminary B, HER2+ and triple-negative, and, that the one with the lowest biological activity would be the luminal subtype A. Thus, the mammography would be more likely to detect cancers with a low degree of biological characteristics such as “luminal A”. The mammary carcinomas with greater potential for systemic dissemination on the other hand, show faster growth in the breast parenchyma; being detected predominantly by self-examination. The knowledge of this difference in the clinical behavior of mammary malignant neoplasms is important for the diagnosis of “interval” breast cancers- that is, breast cancer that appears in the period between the performance of annual screening mammograms.

Objetivos

Verify the relationship between immunohistochemical characterization of malignant breast neoplasms with the finding that motivated the medical consultation, in women with breast cancer and residents in Western Santa Catarina.

Métodos

Observational, cross-sectional study, which included women diagnosed with breast cancer treated at an oncology referral center in the city of Chapecó-SC, during the period from January 2000 to December 2016. Those patients that present data medical record with the main complaint that directed to the diagnosis of breast cancer were included (example: nodule diagnosed by image exams, self-examination, clinical examination). Besides this, the breast injury related to this complaint should have had breast cancer diagnosis by anatomopathological examination and immunohistochemistry study. The project was developed in accordance to CEP/UNOCHAPECO no 1819869.

Resultados

Data from 209 patients were analyzed, of which 83 (39.7%) cases of breast cancer were detected by mammography examination; 115 (55%) for breast self-examination and 11 (5.2%) for other forms of examination, which included clinical breast examination by doctor, magnetic resonance imaging and ultrasound. The immunohistochemical profile luminal A was more prevalent among patients who underwent breast cancer detection through mammography (62.6%) (Table 1). There was a correlation between lymph node invasion and the screening method, in which 78.6% of cancers detected by self-examination showed expansion to lymph nodes, while those detected by mammography presented an invasion rate of 45.7% (p = 0.002) (Table 2).

Conclusões

Breast cancer with immunohistochemical characterization, related to greater biological activity, were most often detected by self-examination, while neoplasms with indolent development were diagnosed predominantly by mammography.

Palavras Chave

Breast cancer; mammography; immunohistochemical exam; self-examination.

Área

DETECTION / DIAGNOSIS - Breast lesion

Instituições

Universidade Comunitária da Região de Chapecó - Santa Catarina - Brasil, Universidade Federal da Fronteira Sul - Santa Catarina - Brasil

Autores

Andre Moreno, Kimberly Masiero Cola, Larissa Heberle, Marcelo Moreno