Dados do Trabalho

Título

A MULTICENTRIC STUDY ON BREAST CANCER IN ULTRA YOUNG WOMEN: III – THERAPEUTIC ASPECTS AND ONCOLOGICAL OUTCOMES

Título em Inglês

A MULTICENTRIC STUDY ON BREAST CANCER IN ULTRA YOUNG WOMEN: III – THERAPEUTIC ASPECTS AND ONCOLOGICAL OUTCOMES

Introdução

Introduction. We have originally introduced the concept of ultra young women (UYW), defined as age ≤ 30 years old. It is generally accepted that UYW patients with breast cancer (BC) share some unfavorable outcomes and the patients are faced with family and professional problems, and unique quality of life issues, including loss of fertility, contraception, pregnancy, sexuality, cancer during pregnancy, body image and emotional distress, that complicate treatment decisions making.

Objetivos

Objective. We adressed to study the type of surgical and systemic treatment and oncologic outcomes in UYW with BC.

Métodos

Methods. We conducted a multicentric, observational, retrospective study of consecutive BC UYW patients. Only patients with infiltrating BC were included. Nine Mastology Centers located in the State of São Paulo participated. The following data were recorded: type of surgery, chemotherapy, endocrinetherapy, and radiotherapy. Individual oncologic evolution was analysed and the patients were classified as alive without disease (AWD), alive with local recurrence (ALR), systemic recurrence (ASR), died for BC (DBC) or died for another cause (DOC). The research protocol was approved by the Ethics Committee of all Collaborative Centers.

Resultados

Results. Sixteen percent of UYW with BC underwent to mastectomies, 10% nipple-sparing mastectomies and 16% breast conservative surgeries. About 50% had immediated breast reconstruction. Sentinel node biopsy were performed in 24%. 18% had more than 4 compromised LNs, 8% with extracapsular extravasament. 37% received adjuvant or palliative chemotherapy. 61% were submitted to irradiation. 54% had adjuvant hormonetherapy. The mean time of follow-up was 41-5 months (1.5-207). It was observed that 59% was AWD, 1% ALR, 7% ASR and 23% DBC, unfortunately standing out the elevated contingent of BC-related deaths.

Conclusões

Conclusions. BC therapy in UYW were tailorized according individual characteristics but the oncological outcomes in this age range at the momment could be considered unfavorable.

Palavras Chave

Área

TREATMENT - Treatment – other