XXIII Congresso Brasileiro de Mastologia

Dados do Trabalho


Título

A MULTICENTRIC STUDY ON BREAST CANCER IN ULTRA YOUNG WOMEN: II – HISTOPATHOLOGIC AND MOLECULAR DATA

Título em Inglês

A MULTICENTRIC STUDY ON BREAST CANCER IN ULTRA YOUNG WOMEN: II – HISTOPATHOLOGIC AND MOLECULAR DATA

Introdução

Introduction. Ultra young women (UYW) is defined as women aged up to 30 years. UYW with BC share some unfavorable biological tumor characteristics as larger size at diagnosis, higher loca-regional recurrence rate and lower survival, and have been merited specialized care.

Objetivos

Objective. We aimed to determine histopathological and molecular characteristics of BC in UYW.

Métodos

Methods. We conducted a multicentric, observational, retrospective study of consecutive UYW patients with BC. Only patients with infiltrating BC were included. Nine Mastology Centers located in the State of São Paulo took part in the research. The follow data were recorded: pathological tumor histology, number of positive lymph nodes multicentricity/multifocality, presence of absence of peritumoral vascular invasion (PVI), histologic grade (HG), pT category, estrogen receptor (ER), progesterone receptor (PgR), HER2 and Ki67. We classified the neoplasias into 5 molecular subtypes by immunohistochemistry, based on modified recommendations of St. Gallen Consensus (2013): Luminal A-like, Luminal B-like HER2-, Luminal B-like HER2+, HER2 overexpressed (HER2+) non luminal and Triple Negative. The frequency of the analysed parameters were calculated. The research protocol was approved by the Ethics Committee of all Collaborative Centers. Individual informed consent was waived.

Resultados

Results. Invasive carcinoma of no special type (NST) was observed in 243 patients (88%), and infiltrative lobular tumor was extremely rare, being found in 1.1%. The tumor size in surgical specimens measured more than 20mm in 54% (in 10% there was no more evidence of tumor after neoadjuvant treatment). We found 52.6% of patients without invasion in lymph nodes (LN) whereas in 22.2% there was more than 4 LNs with involvement. Multifocality was seen in 12.4%. HG was 2 or 3 in 98.3%. In 67.5% the tumors expressed ER, 59.4% PgR, and 25.1% were HER2+. In 61.5% Ki67 was greater than 20%.The tumor molecular subtypes were classified in 16.6% Luminal A-like, 35.9% Luminal B-like HER2-, 15.1% Luminal B-like HER2+, 9.3% HER2+ non luminal and in 22.9% Basal-like.

Conclusões

Conclusion. Our data with UYW with BC revealed unfavorable characteristics, with frequent adverse pathological and molecular prognostic factors.

Palavras Chave

Área

TUMOR CELL, MOLECULAR BIOLOGY, PREDICTIVE AND PROGNOSTIC FACTORS - Tumor cell, molecular biology, predictive and prognostic factors – other

Instituições

Faculdade de Ciências Médicas de Santos - São Paulo - Brasil, Faculdade de Medicina de Jundiaí - São Paulo - Brasil, Hospital da Beneficência Portuguesa - São Paulo - Brasil, Hospital das Clínicas de Botucatu - São Paulo - Brasil, Hospital do Amor - São Paulo - Brasil, Hospital Pérola Byington - São Paulo - Brasil, Hospital Regional de Presidente Prudente - São Paulo - Brasil, Hospital Sírio Libanês - São Paulo - Brasil, Instituto Arnaldo Vieira de Carvalho - São Paulo - Brasil, Instituto do Câncer do Estado de São Paulo - São Paulo - Brasil

Autores

Adriana Akemi Yoshimura, André Mattar, Bruna S. Mota, Carlos Elias Fristachi, Eduardo Carvalho Pessoa, Felipe Eduardo Andrade, Giuliano Tosello, Heloísa Maria de Luca Vespoli, Idam de Oliveira Junior, João Bosco Ramos Borges, José Roberto Filassi, Henrique Gebrim, Marina Filie Haddad Piccinilli, René Aloisio Costa Vieira, Vicente Tarriconi Junior, Alfredo Carlos Simões Dornellas de Barros