Dados do Trabalho
Título
CORRELATION BETWEEN THE PRESENCE OF ANDROGENIC RECEPTORS AND MOLECULAR AND HISTOPATHOLOGICAL VARIABLES IN BREAST CANCER
Título em Inglês
CORRELATION BETWEEN THE PRESENCE OF ANDROGENIC RECEPTORS AND MOLECULAR AND HISTOPATHOLOGICAL VARIABLES IN BREAST CANCER
Introdução
Introduction: The expression of androgenic receptors (AR) is a new predictive marker of response and prognosis in invasive breast carcinoma (CM). It emerges as a potential therapeutic target.
Objetivos
Objective: To evaluate the frequency of RA positivity and its correlation with molecular and histopathological parameters in infiltrative CM.
Métodos
Method: Retrospective cohort study, analyzing 119 cases of non-metastatic invasive CM, seen at a private clinic. Hormonal receptors were screened by immunohistochemical reaction, and AR were considered positive when present in at least 10% of cells, RE and RP from 1%.
This finding was correlated with pathological staging, histological grade (HG), vascular-lymphatic invasion (VLI), estrogen receptors (ER), progesterone receptors (PR), HER2 and Ki 67.
Resultados
Results: AR were positive in 96 cases (80.6%). The correlation with the surveyed parameters can be seen in the table.
Conclusões
Conclusions: AR positivity is associated with more differentiated hormone-dependent tumors and with a lower proliferation rate.
Palavras Chave
Área
TUMOR CELL, MOLECULAR BIOLOGY, PREDICTIVE AND PROGNOSTIC FACTORS - Tumor cell, molecular biology, predictive and prognostic factors – other
Instituições
Department of Pathology, Faculty of Medicine FMUSP, University of Sao Paulo - São Paulo - Brasil, Prof. Alfredo Barros Clinic - São Paulo - Brasil
Autores
BB Geronymo, FM Carvalho , AA Yoshimura , J Z Andrade , DA Andrade , ACSD Barros