XXIII Congresso Brasileiro de Mastologia

Dados do Trabalho


Título

CORRELATION BETWEEN THE PRESENCE OF ANDROGENIC RECEPTORS AND MOLECULAR AND HISTOPATHOLOGICAL VARIABLES IN BREAST CANCER

Título em Inglês

CORRELATION BETWEEN THE PRESENCE OF ANDROGENIC RECEPTORS AND MOLECULAR AND HISTOPATHOLOGICAL VARIABLES IN BREAST CANCER

Introdução

Introduction: The expression of androgenic receptors (AR) is a new predictive marker of response and prognosis in invasive breast carcinoma (CM). It emerges as a potential therapeutic target.

Objetivos

Objective: To evaluate the frequency of RA positivity and its correlation with molecular and histopathological parameters in infiltrative CM.

Métodos

Method: Retrospective cohort study, analyzing 119 cases of non-metastatic invasive CM, seen at a private clinic. Hormonal receptors were screened by immunohistochemical reaction, and AR were considered positive when present in at least 10% of cells, RE and RP from 1%.
This finding was correlated with pathological staging, histological grade (HG), vascular-lymphatic invasion (VLI), estrogen receptors (ER), progesterone receptors (PR), HER2 and Ki 67.

Resultados

Results: AR were positive in 96 cases (80.6%). The correlation with the surveyed parameters can be seen in the table.

Conclusões

Conclusions: AR positivity is associated with more differentiated hormone-dependent tumors and with a lower proliferation rate.

Palavras Chave

Área

TUMOR CELL, MOLECULAR BIOLOGY, PREDICTIVE AND PROGNOSTIC FACTORS - Tumor cell, molecular biology, predictive and prognostic factors – other

Instituições

Department of Pathology, Faculty of Medicine FMUSP, University of Sao Paulo - São Paulo - Brasil, Prof. Alfredo Barros Clinic - São Paulo - Brasil

Autores

BB Geronymo, FM Carvalho , AA Yoshimura , J Z Andrade , DA Andrade , ACSD Barros