Dados do Trabalho

Título

IMPACTO DA RECIDIVA LOCAL EM PACIENTES COM DIAGNOSTICO DE CANCER DE MAMA SUBMETIDAS A CIRURGIA CONSERVADORA NO HOSPITAL DO SERVIDOR PUBLICO ESTADUAL

Título em Inglês

IMPACT OF LOCAL RECURRENCE ON PATIENTS WITH BREAST CANCER DIAGNOSIS SUBMITTED TO CONSERVATIVE SURGERY AT HOSPITAL PUBLICO DO SERVIDOR ESTADUAL

Introdução

Introduction: Breast cancer is a major cause of mortality in Brazil and worldwide. It is a heterogeneous disease with specific molecular subtypes, which are associated with different prognosis and responses to treatment.

Objetivos

Objectives: The present study aims to assess the incidence of local recurrence in patients undergoing conservative surgery and its impact on overall survival. As a secondary outcome, the prognostic factors of local recurrence in addition to the relationship with systemic metastasis.

Métodos

Methods: It is a retrospective cohort including 500 patients submitted conservative surgical treatment, from March 2014 to March 2019 at Hospital do Servidor Público Estadual de São Paulo.

Resultados

Results: The results are compatible with the literature, with local recurrence in 4% of patients and more relapses with triple negative subtype; 367 patients had hormonal treatment: 5 (1.4%) relapsed and 51 patients did not use hormonal treatment 4 (7.8%) relapsed, this shows a higher percentage of recurrence in the group without adjuvant hormone therapy when compared to the group that underwent treatment (p = 0.016) ; 7.4% of patients developed metastasis was more prevalent in patients diagnosed with triple negative subtype and pure Her, this group has an estimated probability of survival significantly lower (72.3%) than the group without metastasis (98%)(p <0.001). In this cohort, disease-free survival was 93.4% and overall survival was 96% over a median of 3 years of follow-up. Other prognostic factors, established in the literature, such as age, lymph node involvement, tumor size, in addition to treatment therapy systemic and radiotherapy had no significant difference between patients did or did not relapse.

Conclusões

Conclusion: In this cohort, patients diagnosed with breast cancer and who underwent conservative surgery, evolving with local recurrence, did not present a higher risk of death and we found tumor biology as a risk factor for locoregional recurrences. Patients who evolved with systemic metastasis observed a reduction in overall survival.

Palavras Chave

Keywords: Breast cancer, breast- conserving therapy, local disease recurrence

Área

TUMOR CELL, MOLECULAR BIOLOGY, PREDICTIVE AND PROGNOSTIC FACTORS - Tumor cell, molecular biology, predictive and prognostic factors – other