Dados do Trabalho
Título
VARIAVEIS PREDITIVAS DE RESPOSTA PATOLOGICA COMPLETA (RPC) NO CARCINOMA DUCTAL INVASIVO
Título em Inglês
PREDICTIVE VARIABLES OF PATHOLOGIC COMPLETE RESPONSE (PCR) IN INVASIVE DUCTAL CARCINOMA
Introdução
Achieving a pCR after neoadjuvant chemotherapy is generally associated with better outcomes. Identifying modifiable and non-modifiable variables that correlates with a complete response is important to treatment.
Objetivos
The aim of this study is to identify clinical and immunohistochemical variables that correlates with pCR, in a public and a private breast cancer unit in the city of Curitiba-Paraná.
Métodos
A retrospective analysis was carried out through medical records at Hospital de Clínicas- UFPR and Centro de Doenças da Mama- Hospital Nossa Senhora das Graças. Patients who underwent surgical treatment after neoadjuvant chemotherapy, in the period from January 1, 2017 to December 31, 2020, due to an invasive ductal carcinoma were selected. Clinical and immunohistochemical variables were correlated to the presence of pCR. Ethical committee approval n. 4.295.049.
Resultados
In 240 cases included, 66 (27,5%) reached pCR. There was a significant correlation between pCR and the negativity of the hormonal receptors (p=0,002), HER2 positivity (p=0,002), Ki67 expression (p=0,012) and molecular subtypes (p=0,001). A ROC curve analysis identified a 50% percentage as the best cut-off value to predict complete response. On the other hand, it was not observed a significant correlation between pCR and body mass index, or physical activity.
Conclusões
There is a strong correlation between immunohistochemical parameters and pCR. Further studies are needed to determine the correlation between modifiable variables.
Palavras Chave
Breast Cancer; Neoadjuvant Chemotherapy; Pathologic Complete Response
Área
TUMOR CELL, MOLECULAR BIOLOGY, PREDICTIVE AND PROGNOSTIC FACTORS - Predictive Biomarkers
Instituições
CENTRO DE DOENÇAS DA MAMA- CDM - Paraná - Brasil, UNIVERSIDADE FEDERAL DO PARANÁ - Paraná - Brasil
Autores
IRIS RABINOVICH, ISABELA CHAVES MONTEIRO SOARES, JULIA MIZRAHI JAKOBSON, EDUARDO MILLEO KAC, BRUNO LUIZ ZONTA