XXIII Congresso Brasileiro de Mastologia

Dados do Trabalho


Título

VARIAVEIS PREDITIVAS DE RESPOSTA PATOLOGICA COMPLETA (RPC) NO CARCINOMA DUCTAL INVASIVO

Título em Inglês

PREDICTIVE VARIABLES OF PATHOLOGIC COMPLETE RESPONSE (PCR) IN INVASIVE DUCTAL CARCINOMA

Introdução

Achieving a pCR after neoadjuvant chemotherapy is generally associated with better outcomes. Identifying modifiable and non-modifiable variables that correlates with a complete response is important to treatment.

Objetivos

The aim of this study is to identify clinical and immunohistochemical variables that correlates with pCR, in a public and a private breast cancer unit in the city of Curitiba-Paraná.

Métodos

A retrospective analysis was carried out through medical records at Hospital de Clínicas- UFPR and Centro de Doenças da Mama- Hospital Nossa Senhora das Graças. Patients who underwent surgical treatment after neoadjuvant chemotherapy, in the period from January 1, 2017 to December 31, 2020, due to an invasive ductal carcinoma were selected. Clinical and immunohistochemical variables were correlated to the presence of pCR. Ethical committee approval n. 4.295.049.

Resultados

In 240 cases included, 66 (27,5%) reached pCR. There was a significant correlation between pCR and the negativity of the hormonal receptors (p=0,002), HER2 positivity (p=0,002), Ki67 expression (p=0,012) and molecular subtypes (p=0,001). A ROC curve analysis identified a 50% percentage as the best cut-off value to predict complete response. On the other hand, it was not observed a significant correlation between pCR and body mass index, or physical activity.

Conclusões

There is a strong correlation between immunohistochemical parameters and pCR. Further studies are needed to determine the correlation between modifiable variables.

Palavras Chave

Breast Cancer; Neoadjuvant Chemotherapy; Pathologic Complete Response

Área

TUMOR CELL, MOLECULAR BIOLOGY, PREDICTIVE AND PROGNOSTIC FACTORS - Predictive Biomarkers

Instituições

CENTRO DE DOENÇAS DA MAMA- CDM - Paraná - Brasil, UNIVERSIDADE FEDERAL DO PARANÁ - Paraná - Brasil

Autores

IRIS RABINOVICH, ISABELA CHAVES MONTEIRO SOARES, JULIA MIZRAHI JAKOBSON, EDUARDO MILLEO KAC, BRUNO LUIZ ZONTA