Dados do Trabalho

Título

PERFIL IMUNOHISTOQUIMICO ESTRATIFICADO EM FAIXA ETARIA EM 11326 PACIENTES N O SUS SAO PAULO

Título em Inglês

IMMUNOHISTOCHEMICAL PROFILE STRATIFIED IN AGE RANGE IN
11326 PATIENTS IN SUS SÃO PAULO.

Introdução

The development of breast cancer is heterogeneous and there are variations in
its morphology and biological characteristics. Several risk factors for cancer
breast cancer have already been identified, including the age group.
It is well established that the incidence of breast cancer increases the partie
65 years old. Older patients are more likely to have tumors
which are positive estrogen receptors (ER) and progesterone receptor (RP)
and, HER2 negative, which are associated with better outcomes. In
In contrast, younger patients with triple-negative breast cancer and HER2
positive and is associated with reduced survival and poor prognosis.

Objetivos

To evaluate immunohistochemical profiles stratified by age group in patients
diagnosed with breast cancer at Perola Byington Hospital.

Métodos

A retrospective cross-sectional study was carried out at the Referral Center for Women’s Health - Hospital PerolaByington, São Paulo, Brazil. The data were
removed from the collection system during the period between January 2011 to
December 2018. Such women were stratified through the subtype
histochemical analysis and evaluated in relation to the age of diagnosis.

Resultados

We analyzed the immunohistochemical profile of 11326 patients treated at the Hospital Pérola Byington from January 2011 to December 2018. Lumum tumors A corresponded to 2629 cases and among these 7.3% were under 40 years old, 23.1%
between 40 and 50 years old and 60.5% were over 50 years old. The rate of tumors lumen B was 3494 cases, with 10.1% in patients under 40 24.2% between 40 and 50 years old and 65.6% over 50 years old.
Acheampong et al, carried out a study on the incidence of molecular subtypes in the USA between 2010 and 2016 and concluded that of the 320124 women included, 72.6% were classified as luminal A, 11.2% luminal B, 4.8% overexpression of HER2 and 11.3% tumors

Conclusões

Based on the molecular markers, we classified the subtypes into four breast carcinomas: luminal B was the most frequent, followed by luminal A -the subtypes showed no significant difference in relation to the type histological nor age.
Thus, the correlation between histological diagnosis and immunohistochemistry can
improve the treatment and survival of women with breast cancer and,consequently, improving the therapeutic response of patients.

Palavras Chave

Breast cancer;IMMUNOHISTOCHEMICAL breast cancer; stratified breast cancer

Área

TUMOR CELL, MOLECULAR BIOLOGY, PREDICTIVE AND PROGNOSTIC FACTORS - Biomarkers